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Model‐Informed Recommendation of Mavacamten Posology for Chinese Adults With Obstructive Hypertrophic Cardiomyopathy

ABSTRACT Mavacamten is a cardiac myosin inhibitor for adults with obstructive hypertrophic cardiomyopathy (HCM). Dose optimization is performed 4 weeks after starting mavacamten, guided by periodic echo measurements of Valsalva left ventricular outflow tract gradient (VLVOTg) and left ventricular ej...

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Principais autores: Xiaojie Wu, Shilpa Puli, Nanye Chen, Zhuang Tian, Peiwen Hsu, Jing Sun, Cheng Lyu, Samira Merali, Jing Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-04-01
Serier:CPT: Pharmacometrics & Systems Pharmacology
Fag:
dose
efficacy
ethnicity
exposure response
model evaluation
model‐based drug development
Online adgang:https://doi.org/10.1002/psp4.13312
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