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The SRSF3-MBNL1-Acin1 circuit constitutes an emerging axis to lessen DNA fragmentation in colorectal cancer via an alternative splicing mechanism

ABSTRACT: Altered alternative splicing (AS) events are considered pervasive causes that result in the development of carcinogenesis. Herein, we identified reprogrammed expression and splicing profiles of Muscle blind-like protein 1 (MBNL1) transcripts in tumorous tissues compared to those of adjacen...

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Main Authors: Yi-Su Chen, Chao-Wei Liu, Ying-Chin Lin, Chia-Ying Tsai, Ching-Hui Yang, Jung-Chun Lin
Format: Artigo
Language:Inglês
Published: Elsevier 2020-12-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Acin1
Alternative splicing
Colorectal cancer
MBNL
SRSF3
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558620301573
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