Two New Dihydrosphingosine Analogs Against Mycobacterium tuberculosis Affect gltA1, lprQ, and rpsO Expression

The emergence of multidrug-resistant (MDR) Mycobacterium tuberculosis strains threaten the control of tuberculosis. New antitubercular dihydrosphingosine analogs, named UCIs, have been evaluated in preclinical studies but their cellular and molecular mechanisms of action against M. tuberculosis are...

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Detalhes bibliográficos

Principais autores:	Katia Peñuelas-Urquides, Mario Bermúdez de León, Beatriz Silva-Ramírez, Fabiola Castorena-Torres, Gloria María Molina-Salinas, Jorge Castro-Garza, Pola Becerril-Montes, Esther del Olmo, Arturo San Feliciano, Laura Adiene González-Escalante, Licet Villarreal-Treviño, Salvador Said-Fernández
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-11-01
coleção:	Frontiers in Microbiology
Assuntos:	Mycobacterium tuberculosis multidrug-resistance gene expression antitubercular drugs dihydrosphingosine analogs
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fmicb.2021.742867/full
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