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Synergistic effect of inhibiting CHK2 and DNA replication on cancer cell growth

Cancer cells display high levels of oncogene-induced replication stress (RS) and rely on DNA damage checkpoint for viability. This feature is exploited by cancer therapies to either increase RS to unbearable levels or inhibit checkpoint kinases involved in the DNA damage response. Thus far, treatmen...

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Kaydedildi:
Asıl Yazarlar: Flavie Coquel, Sing-Zong Ho, Keng-Chang Tsai, Chun-Yen Yang, Antoine Aze, Julie Devin, Ting-Hsiang Chang, Marie Kong-Hap, Audrey Bioteau, Jerome Moreaux, Domenico Maiorano, Philippe Pourquier, Wen-Chin Yang, Yea-Lih Lin, Philippe Pasero
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications Ltd 2025-01-01
Seri Bilgileri:eLife
Konular:
DNA replication
DNA repair
cancer
Online Erişim:https://elifesciences.org/articles/104718
Etiketler: Etiketle
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