Inducing DNA damage through R-loops to kill cancer cells
R-loops are intermediate structures of transcription that can accumulate when transcriptional elongation is blocked by inhibiting BRD4. In normal cells, R-loop persistence suppresses firing of adjacent replication origins. This control is lost in a subset of cancer cells, where BRD4 inhibition resul...
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| Principais autores: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis Group
2021-01-01
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| Serier: | Molecular & Cellular Oncology |
| Fag: | |
| Online adgang: | http://dx.doi.org/10.1080/23723556.2020.1848233 |
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