Targeting p53–MDM2 interaction by small-molecule inhibitors: learning from MDM2 inhibitors in clinical trials

Abstract p53, encoded by the tumor suppressor gene TP53, is one of the most important tumor suppressor factors in vivo and can be negatively regulated by MDM2 through p53–MDM2 negative feedback loop. Abnormal p53 can be observed in almost all tumors, mainly including p53 mutation and functional inac...

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Hauptverfasser:	Haohao Zhu, Hui Gao, Yingying Ji, Qin Zhou, Zhiqiang Du, Lin Tian, Ying Jiang, Kun Yao, Zhenhe Zhou
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2022-07-01
Schriftenreihe:	Journal of Hematology & Oncology
Schlagworte:	p53 MDM2 Inhibitor Multi-target Degrader
Online-Zugang:	https://doi.org/10.1186/s13045-022-01314-3
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