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Synthesis and Biological Evaluation of S-, O- and Se-Containing Dispirooxindoles

A series of novel S-, O- and Se-containing dispirooxindole derivatives has been synthesized using 1,3-dipolar cycloaddition reaction of azomethine ylide generated from isatines and sarcosine at the double C=C bond of 5-indolidene-2-chalcogen-imidazolones (chalcogen was oxygen, sulfur or selenium). T...

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Principais autores: Maksim Kukushkin, Vladimir Novotortsev, Vadim Filatov, Yan Ivanenkov, Dmitry Skvortsov, Mark Veselov, Radik Shafikov, Anna Moiseeva, Nikolay Zyk, Alexander Majouga, Elena Beloglazkina
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-12-01
Serier:Molecules
Fag:
dispirooxindoles
anticancer activity
cytotoxicity
3D molecular docking
p53/MDM2 interaction
Online adgang:https://www.mdpi.com/1420-3049/26/24/7645
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