Harnessing DNA Repair Defects to Augment Immune-Based Therapies in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) has poor prognosis with limited treatment options, with little therapeutic progress made during the past several decades. DNA damage response (DDR) associated therapies, including radiation and inhibitors of DDR, demonstrate potential efficacy against TNBC, espec...

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Κύριοι συγγραφείς:	Curtis A. Clark, Eddy S. Yang
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2021-09-01
Σειρά:	Frontiers in Oncology
Θέματα:	TNBC DNA repair immunotherapy PARP inhibition (PARPi) PD-1 - PD-L1 axis DDR (DNA damage response)
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fonc.2021.703802/full
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