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PA2G4 Functions as a Cofactor for MYC Family Oncoproteins in MYC-Driven Malignancies

MYCN and c-MYC are critical driver oncogenes in several childhood cancers, including neuroblastoma. Currently, the clinical development of MYC inhibitors has been hindered by the intrinsically disordered structure of MYC proteins, which lack well-defined ligand-binding pockets. Proliferation-associa...

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Principais autores: Sukriti Krishan, Jessica Koach, Taylor Lim, Kenny Yeo, Faith Cheong, Jie-Si Luo, Hassina Massudi, Xiaomian Gao, Sopheakwealthy Heangsarath, Andrew J. Kueh, Marco J. Herold, Belamy B. Cheung, Glenn M. Marshall
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-09-01
coleção:Cells
Assuntos:
MYC
MYCN
PA2G4
neuroblastoma
Burkitt’s lymphoma
inhibitors
Acesso em linha:https://www.mdpi.com/2073-4409/14/18/1422
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