Platform design of hybrid microphysiological system integrating in vitro and in silico models for reproducing insulin-regulated glucose metabolism

Abstract This study presents a hybrid platform for microphysiological systems (MPS) that combines in vitro organ-on-a-chip (OoC) technology and an in silico model. In this platform, in silico models act as virtual organs that interact with real OoCs, enabling the stimulation of multi-organ interacti...

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Váldodahkkit:	Satoshi Konishi, Shunsuke Kotera, Tomotaka Minamikawa, Fumiyoshi Yamashita, Takuya Fujita
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Nature Portfolio 2026-04-01
Ráidu:	Scientific Reports
Fáttát:	Microphysiological system Organ-on-a-chip In silico modeling Skeletal muscle Insulin–glucose metabolism Hybrid MPS platform
Liŋkkat:	https://doi.org/10.1038/s41598-026-49605-w
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