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Netrin-1-UNC5B/neogenin axis enhances the stemness of colorectal cancer cells

Abstract Cancer stem cells were prominent responsible for cancer initiation, metastasis, and invasion as well as therapeutic resistance in colorectal cancer (CRC). The extracellular axon guidance factor netrin-1 has been found to be overexpressed in several malignant cancers such as glioma, lung can...

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Main Authors: Xueli Xia, Zhenwei Mao, Wenxin Wang, Lin Zhao, Mengxue Xu, Jie Ma, Jie Tian, Kai Yin, Shengjun Wang
Format: Artigo
Language:Inglês
Published: BMC 2025-11-01
Series:Cell Communication and Signaling
Subjects:
Netrin-1
UNC5B
Neogenin
NF-κB
ERK1/2
Cancer stemness
Online Access:https://doi.org/10.1186/s12964-025-02489-1
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