A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response

Abstract Eukaryotic initiation factor 2B (eIF2B), a guanine nucleotide exchange factor (GEF), promotes protein synthesis by charging translation initiation factor 2 (eIF2) with GTP. Stress-induced phosphorylation of eIF2 on its α-subunit [eIF2(αP)] inhibits this reaction triggering a protective Inte...

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主要な著者:	Fiona Shilliday, Miguel Gancedo-Rodrigo, Ginto George, Shintaro Aibara, Santosh Adhikari, Syedah Neha Ashraf, Evelyne J. Barrey, Paolo A. Centrella, Damian Crowther, Paige Dickson, Diana Gikunju, Marie-Aude Guié, John P. Guilinger, Anders Gunnarsson, Heather P. Harding, Christopher D. Hupp, Rachael Jetson, Anthony D. Keefe, JeeSoo Monica Kim, Richard J. Lewis, Taiana Maia de Oliveira, Jennifer Le-Marshall, Usha Narayanan, Katherine A. Nugai, Dušan Petrović, Emma Rivers, David Ron, Daisy Stringfellow, Karl Syson, Lewis Ward, John T. S. Yeoman, Yan Yu, Ying Zhang, Alisa Zyryanova, David J. Baker, Perla Breccia, John E. Linley
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2026-05-01
シリーズ:	Nature Communications
オンライン･アクセス:	https://doi.org/10.1038/s41467-026-72688-y
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