A prometabolite strategy inhibits cardiometabolic disease in an ApoE–/– murine model of atherosclerosis

Butyrate, a microbiome-derived short-chain fatty acid with pleiotropic effects on inflammation and metabolism, has been shown to significantly reduce atherosclerotic lesions, rectify routine metabolic parameters such as low-density lipoprotein cholesterol (LDL-C), and reduce systemic inflammation in...

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Hlavní autoři:	Taryn N. Beckman, Lisa R. Volpatti, Salvador Norton de Matos, Anna J. Slezak, Joseph W. Reda, Ada Weinstock, Leah Ziolkowski, Alex Turk, Erica Budina, Shijie Cao, Gustavo Borjas, Jung Woo Kwon, Orlando deLeon, Kirsten C. Refvik, Abigail L. Lauterbach, Suzana Gomes, Eugene B. Chang, Jeffrey A. Hubbell
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Clinical investigation 2025-08-01
Edice:	JCI Insight
Témata:	Inflammation Therapeutics
On-line přístup:	https://doi.org/10.1172/jci.insight.191090
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!