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A prometabolite strategy inhibits cardiometabolic disease in an ApoE–/– murine model of atherosclerosis

Butyrate, a microbiome-derived short-chain fatty acid with pleiotropic effects on inflammation and metabolism, has been shown to significantly reduce atherosclerotic lesions, rectify routine metabolic parameters such as low-density lipoprotein cholesterol (LDL-C), and reduce systemic inflammation in...

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Principais autores: Taryn N. Beckman, Lisa R. Volpatti, Salvador Norton de Matos, Anna J. Slezak, Joseph W. Reda, Ada Weinstock, Leah Ziolkowski, Alex Turk, Erica Budina, Shijie Cao, Gustavo Borjas, Jung Woo Kwon, Orlando deLeon, Kirsten C. Refvik, Abigail L. Lauterbach, Suzana Gomes, Eugene B. Chang, Jeffrey A. Hubbell
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical investigation 2025-08-01
Serier:JCI Insight
Fag:
Inflammation
Therapeutics
Online adgang:https://doi.org/10.1172/jci.insight.191090
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