Defective protein persulfidation is involved in obesity associated skeletal muscle dysfunction: role of SIRT-1

Ectopic fat deposition in skeletal muscle (SKM) due to obesity leads to biochemical and morphological alterations that deteriorate SKM quality and performance. Here, we show that impaired MPST-derived hydrogen sulfide (H2S) signaling contributes to obesity-related SKM dysfunction. Muscle tissues fro...

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Главные авторы:	M. Smimmo, V. Casale, D. D'Andrea, I. Bello, N. Iaccarino, F. Romano, V. Brancaleone, E. Panza, R. d’Emmanuele di Villa Bianca, A. Katsouda, E. Mitidieri, I. Antoniadou, A. Papapetropoulos, F. Maione, S. Castaldo, M. Friuli, A. Romano, S. Gaetani, R. Sorrentino, A. Randazzo, G. Cirino, M. Bucci, M. Filipovic, V. Vellecco
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Elsevier 2025-06-01
Серии:	Redox Biology
Предметы:	H2S donors Skeletal muscle Persulfidation Sodium palmitate Db/db mice
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2213231725001582
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