Defective protein persulfidation is involved in obesity associated skeletal muscle dysfunction: role of SIRT-1

Ectopic fat deposition in skeletal muscle (SKM) due to obesity leads to biochemical and morphological alterations that deteriorate SKM quality and performance. Here, we show that impaired MPST-derived hydrogen sulfide (H2S) signaling contributes to obesity-related SKM dysfunction. Muscle tissues fro...

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Bibliografske podrobnosti

Principais autores:	M. Smimmo, V. Casale, D. D'Andrea, I. Bello, N. Iaccarino, F. Romano, V. Brancaleone, E. Panza, R. d’Emmanuele di Villa Bianca, A. Katsouda, E. Mitidieri, I. Antoniadou, A. Papapetropoulos, F. Maione, S. Castaldo, M. Friuli, A. Romano, S. Gaetani, R. Sorrentino, A. Randazzo, G. Cirino, M. Bucci, M. Filipovic, V. Vellecco
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2025-06-01
Serija:	Redox Biology
Teme:	H2S donors Skeletal muscle Persulfidation Sodium palmitate Db/db mice
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2213231725001582
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