Design, Synthesis, and Biological Evaluation of Novel Phenoxy Acetic Acid Derivatives as Selective COX-2 Inhibitors Coupled with Comprehensive Bio-Pharmacological Inquiry, Histopathological Profiling, and Toxicological Scrutiny

COX-2 plays a key role in converting arachidonic acid into prostaglandins. This makes it a significant target for treating inflammation. Selective COX-2 inhibitors have marked a new phase in inflammatory treatment, providing significant effectiveness while reducing negative side effects. Herein, we...

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Hlavní autoři:	Najla A. Alshaye, Mohamed K. Elgohary, Mahmoud S. Elkotamy, Hatem A. Abdel-Aziz
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2024-03-01
Edice:	Molecules
Témata:	anti-inflammatory COX-1/COX-2 paw edema model PGE-2 ulcerogenic effects
On-line přístup:	https://www.mdpi.com/1420-3049/29/6/1309
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