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Design, Synthesis, and Biological Evaluation of Novel Phenoxy Acetic Acid Derivatives as Selective COX-2 Inhibitors Coupled with Comprehensive Bio-Pharmacological Inquiry, Histopathological Profiling, and Toxicological Scrutiny

COX-2 plays a key role in converting arachidonic acid into prostaglandins. This makes it a significant target for treating inflammation. Selective COX-2 inhibitors have marked a new phase in inflammatory treatment, providing significant effectiveness while reducing negative side effects. Herein, we...

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Principais autores: Najla A. Alshaye, Mohamed K. Elgohary, Mahmoud S. Elkotamy, Hatem A. Abdel-Aziz
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-03-01
Serier:Molecules
Fag:
anti-inflammatory
COX-1/COX-2
paw edema model
PGE-2
ulcerogenic effects
Online adgang:https://www.mdpi.com/1420-3049/29/6/1309
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