Mechanistic multiscale modeling identifies putative natural tri-target candidates of MAO-B, LRRK2 and A₂A for Parkinson’s disease

Abstract Parkinson’s disease (PD) is a rapidly growing neurodegenerative disorder for which current dopaminergic and device-based therapies remain purely symptomatic and fail to modify disease progression. Addressing the multifactorial biology of PD under stringent blood-brain barrier constraints re...

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Autors principals:	Oussama Khibech, Salma Kadda, Said Abadi, Abdessamad Benabbou, Mohamed Bouhrim, Shehdeh Jodeh, Diana Jodeh, Belkheir Hammouti, Allal Challioui
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-05-01
Col·lecció:	Scientific Reports
Matèries:	Parkinson’s disease ADMET-AI MD MM/GBSA PCA Good Health and Well-being
Accés en línia:	https://doi.org/10.1038/s41598-026-50523-0
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