Design, Synthesis, and In Vitro Enzymatic Evaluation of Novel Flavone Derivatives as Dual COX-2/5-LOX Inhibitors Supported by Molecular Docking and ADMET Analysis

The development of new anti-inflammatory agents with improved safety and efficacy remains a major therapeutic challenge, particularly in light of the adverse effects associated with conventional nonsteroidal anti-inflammatory drugs. In this study, a series of new flavone derivatives were synthesized...

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Principais autores:	Elmehdi Fraj, Amine Elbouzidi, Haytham Bouammali, Hanane Jaouani, Chaymae Bourhou, Mohamed Addi, Susu M. Zughaier, Allal Challioui, Rachid Touzani, Boufelja Bouammali
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-02-01
coleção:	Current Issues in Molecular Biology
Assuntos:	flavone–tetrazole hybrids anti-inflammatory activities COX-2 5-LOX molecular docking ADMET
Acesso em linha:	https://www.mdpi.com/1467-3045/48/3/243
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