The MEK/ERK pathway promotes NOTCH signalling in pancreatic cancer cells.
Activation of the NOTCH receptors relies on their intracellular proteolysis by the gamma-secretase complex. This cleavage liberates the NOTCH intracellular domain (NIC) thereby allowing the translocation of NIC towards the nucleus to assemble into a transcriptional platform. Little information is av...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Public Library of Science (PLoS)
2013-01-01
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| Cyfres: | PLoS ONE |
| Mynediad Ar-lein: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0085502&type=printable |
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