PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1
Abstract Background The oncogenic PIM kinases and the tumor-suppressive LKB1 kinase have both been implicated in the regulation of cell growth and metabolism, albeit in opposite directions. Here we investigated whether these kinases interact with each other to influence AMPK activation and tumorigen...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BMC
2021-06-01
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| Collection: | Cell Communication and Signaling |
| Sujets: | |
| Accès en ligne: | https://doi.org/10.1186/s12964-021-00749-4 |
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