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Small molecule inhibition of ubiquitin C-terminal hydrolase L1 alters cell metabolism proteins and exerts anti- or pro-tumorigenic effects contingent upon chemosensitivity status in high grade serous ovarian cancer

High grade serous ovarian cancer (HGSOC) is the most lethal of all gynecologic malignancies in which the majority of patients eventually develop chemoresistant recurrent disease. Ubiquitin C-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme canonically known for its involvement in neurodege...

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Principais autores: Corinne Jansen, Julia McAdams, Chloe Kim, Payton De La Cruz, Angelica Salaverria, Nicholas A. DaSilva, Kathryn Grive, Nicole E. James
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-02-01
coleção:Frontiers in Pharmacology
Assuntos:
high grade serous ovarian cancer (HGSOC)
chemoresisitance
chemosensitivity
LDN-57444
Uchl1
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2025.1547164/full
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