Small molecule inhibition of ubiquitin C-terminal hydrolase L1 alters cell metabolism proteins and exerts anti- or pro-tumorigenic effects contingent upon chemosensitivity status in high grade serous ovarian cancer

High grade serous ovarian cancer (HGSOC) is the most lethal of all gynecologic malignancies in which the majority of patients eventually develop chemoresistant recurrent disease. Ubiquitin C-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme canonically known for its involvement in neurodege...

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Библиографические подробности

Главные авторы:	Corinne Jansen, Julia McAdams, Chloe Kim, Payton De La Cruz, Angelica Salaverria, Nicholas A. DaSilva, Kathryn Grive, Nicole E. James
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2025-02-01
Серии:	Frontiers in Pharmacology
Предметы:	high grade serous ovarian cancer (HGSOC) chemoresisitance chemosensitivity LDN-57444 Uchl1
Online-ссылка:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1547164/full
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