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Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol

Abstract Mitochondrial dysfunction is associated with numerous acute and chronic degenerative diseases. The beta-2 adrenergic receptor (β2AR) agonist formoterol induces mitochondrial biogenesis (MB), but other β2AR agonists, such as clenbuterol, do not. We sought to identify the MB signaling pathway...

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Bibliografiske detaljer
Principais autores: Robert B. Cameron, Yuri K. Peterson, Craig C. Beeson, Rick G. Schnellmann
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2017-09-01
Serier:Scientific Reports
Online adgang:https://doi.org/10.1038/s41598-017-11030-5
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