Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol
Abstract Mitochondrial dysfunction is associated with numerous acute and chronic degenerative diseases. The beta-2 adrenergic receptor (β2AR) agonist formoterol induces mitochondrial biogenesis (MB), but other β2AR agonists, such as clenbuterol, do not. We sought to identify the MB signaling pathway...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Portfolio
2017-09-01
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| Collection: | Scientific Reports |
| Accès en ligne: | https://doi.org/10.1038/s41598-017-11030-5 |
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