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Advances in Small-Molecule C-KIT/PDGFRα Inhibitors for the Treatment of Gastrointestinal Stromal Tumors

Stem cell factor receptor (C-KIT) or platelet-derived growth factor receptor α (PDGFRα) gene mutations have been identified as oncogenic drivers for most gastrointestinal stromal tumors (GISTs). Thus, small-molecule inhibitors of C-KIT or PDGFRα have emerged as effective treatments for GISTs. Althou...

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Principais autores: Xuan Zheng, Hong Liang, Yang Zhou, Xiaoyun Lu
Format: Artigo
Sprog:Inglês
Udgivet: Georg Thieme Verlag KG 2024-12-01
Serier:Pharmaceutical Fronts
Fag:
PDGFRα
C-KIT
GISTs
kinase inhibitors
clinical resistance
Online adgang:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1791541
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