Premedication with pioglitazone prevents doxorubicin-induced left ventricular dysfunction in mice

Abstract Background Doxorubicin (DOX) is widely used as an effective chemotherapeutic agent for cancers; however, DOX induces cardiac toxicity, called DOX-induced cardiomyopathy. Although DOX-induced cardiomyopathy is known to be associated with a high cumulative dose of DOX, the mechanisms of its l...

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Autors principals:	Takaaki Furihata, Satoshi Maekawa, Shingo Takada, Naoya Kakutani, Hideo Nambu, Ryosuke Shirakawa, Takashi Yokota, Shintaro Kinugawa
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2021-05-01
Col·lecció:	BMC Pharmacology and Toxicology
Matèries:	Anticancer agent LV dysfunction Cardiac toxicity Thiazolidinediones
Accés en línia:	https://doi.org/10.1186/s40360-021-00495-w
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