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Protein acetylation in skeletal muscle mitochondria is involved in impaired fatty acid oxidation and exercise intolerance in heart failure

Abstract Background Exercise intolerance is a common clinical feature and is linked to poor prognosis in patients with heart failure (HF). Skeletal muscle dysfunction, including impaired energy metabolism in the skeletal muscle, is suspected to play a central role in this intolerance, but the underl...

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Principais autores: Masaya Tsuda, Arata Fukushima, Junichi Matsumoto, Shingo Takada, Naoya Kakutani, Hideo Nambu, Katsuma Yamanashi, Takaaki Furihata, Takashi Yokota, Koichi Okita, Shintaro Kinugawa, Toshihisa Anzai
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2018-10-01
Serier:Journal of Cachexia, Sarcopenia and Muscle
Fag:
Heart failure
Exercise intolerance
Lysine acetylation
Skeletal muscle metabolism
Fatty acid oxidation
Online adgang:https://doi.org/10.1002/jcsm.12322
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