Protein acetylation in skeletal muscle mitochondria is involved in impaired fatty acid oxidation and exercise intolerance in heart failure

Abstract Background Exercise intolerance is a common clinical feature and is linked to poor prognosis in patients with heart failure (HF). Skeletal muscle dysfunction, including impaired energy metabolism in the skeletal muscle, is suspected to play a central role in this intolerance, but the underl...

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Autori principali:	Masaya Tsuda, Arata Fukushima, Junichi Matsumoto, Shingo Takada, Naoya Kakutani, Hideo Nambu, Katsuma Yamanashi, Takaaki Furihata, Takashi Yokota, Koichi Okita, Shintaro Kinugawa, Toshihisa Anzai
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2018-10-01
Serie:	Journal of Cachexia, Sarcopenia and Muscle
Soggetti:	Heart failure Exercise intolerance Lysine acetylation Skeletal muscle metabolism Fatty acid oxidation
Accesso online:	https://doi.org/10.1002/jcsm.12322
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