Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling

The demethylase activity of KDM5A is allosterically enhanced by binding of histone H3 to its PHD1 reader domain, through an unknown mechanism. Here the authors show that the PHD1 domain drives ligand-induced allosteric stimulation by stabilizing the binding of substrate to the catalytic domain.

Detalhes bibliográficos

Principais autores:	James E. Longbotham, Cynthia M. Chio, Venkatasubramanian Dharmarajan, Michael J. Trnka, Idelisse Ortiz Torres, Devrishi Goswami, Karen Ruiz, Alma L. Burlingame, Patrick R. Griffin, Danica Galonić Fujimori
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2019-01-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-018-07829-z
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