Substituents introduction of methyl and methoxy functional groups on resveratrol stabilizes mTOR binding for autophagic cell death induction

Abstract The regulation of the mammalian target of rapamycin (mTOR) protein by cancer cells can lead to uncontrol of cancer cell growth and cancer therapy resistance. The drug discovery of the anticancer agent 5-(3-hydroxy-4-methoxyphenethyl)-2-methoxy-3-methylphenol (SM-3), a derivative of resverat...

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Detalhes bibliográficos

Principais autores:	Zin Zin Ei, Satapat Racha, Preedakorn Chunhacha, Masashi Yokoya, Sohsuke Moriue, Hongbin Zou, Pithi Chanvorachote
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-04-01
coleção:	Scientific Reports
Assuntos:	Autophagy Stem cells mTOR Lung cancer Resveratrol SM-3
Acesso em linha:	https://doi.org/10.1038/s41598-025-98616-6
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