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Structural modification of resveratrol analogue exhibits anticancer activity against lung cancer stem cells via suppression of Akt signaling pathway

Abstract Background Compound with cancer stem cell (CSC)-suppressing activity is promising for the improvement of lung cancer clinical outcomes. Toward this goal, we discovered the CSC-targeting activity of resveratrol (RES) analog moscatilin (MOS). With slight structural modification from RES, MOS...

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Hlavní autoři: Sunisa Thongsom, Satapat Racha, Korrakod Petsri, Zin Zin Ei, Kittichate Visuttijai, Sohsuke Moriue, Masashi Yokoya, Pithi Chanvorachote
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2023-06-01
Edice:BMC Complementary Medicine and Therapies
Témata:
Moscatilin
Resveratrol
Lung cancer
Akt pathway
CSCs
Molecular docking
On-line přístup:https://doi.org/10.1186/s12906-023-04016-6
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