annATAC: automatic cell type annotation for scATAC-seq data based on language model

Abstract Background Cell type annotation serves as the cornerstone for downstream analysis of single cell data. Nevertheless, scATAC-seq data is characterized by high sparsity and dimensionality, presenting significant challenges to its annotation process. Results We introduce a novel method based o...

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Detalhes bibliográficos

Principais autores:	Lingyu Cui, Fang Wang, Hongfei Li, Qiaoming Liu, Murong Zhou, Guohua Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-05-01
coleção:	BMC Biology
Assuntos:	Single cell epigenomics Automatic annotation Language model Pre-training Fine-tuning
Acesso em linha:	https://doi.org/10.1186/s12915-025-02244-5
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