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Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesity

Objective: Insulin resistance causes type 2 diabetes mellitus and hyperglycemia due to excessive hepatic glucose production and inadequate peripheral glucose uptake. Our objectives were to test the hypothesis that the proposed CREB/CRTC2 inhibitor salt inducible kinase 1 (SIK1) contributes to whole...

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Furkejuvvon:
Váldodahkkit: Mark Nixon, Randi Stewart-Fitzgibbon, Jingqi Fu, Dmitry Akhmedov, Kavitha Rajendran, Maria G. Mendoza-Rodriguez, Yisel A. Rivera-Molina, Micah Gibson, Eric D. Berglund, Nicholas J. Justice, Rebecca Berdeaux
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Elsevier 2016-01-01
Ráidu:Molecular Metabolism
Fáttát:
SIK1
Salt inducible kinase
CRTC
Gluconeogenesis
Insulin resistance
CREB
Liŋkkat:http://www.sciencedirect.com/science/article/pii/S2212877815001994
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