Functional characterization of 11 novel rhoptry proteins in the type I RH strain of Toxoplasma gondii using the CRISPR-Cas9 system

Abstract Background Rhoptry proteins (ROPs) are secreted effectors that play important roles in the virulence of Toxoplasma gondii by facilitating host cell invasion and immune modulation. Although many ROPs have been predicted, their specific functions remain largely unexplored. This study investig...

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Autors principals:	Hong-Yu Song, Hui Cao, Shi-Bo Huang, Hany M. Elsheikha, Zhi Zheng, Xin-Sheng Lu, Xing Tian, Xiao-Nan Zheng, Xing-Quan Zhu
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-04-01
Col·lecció:	Parasites & Vectors
Matèries:	Toxoplasma gondii Rhoptry proteins Clustered regularly interspaced short palindromic repeats Clustered regularly interspaced short palindromic repeats-associated protein 9 Virulence Transcriptomics
Accés en línia:	https://doi.org/10.1186/s13071-026-07387-0
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