Functional characterization of 11 novel rhoptry proteins in the type I RH strain of Toxoplasma gondii using the CRISPR-Cas9 system

Abstract Background Rhoptry proteins (ROPs) are secreted effectors that play important roles in the virulence of Toxoplasma gondii by facilitating host cell invasion and immune modulation. Although many ROPs have been predicted, their specific functions remain largely unexplored. This study investig...

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Hlavní autoři:	Hong-Yu Song, Hui Cao, Shi-Bo Huang, Hany M. Elsheikha, Zhi Zheng, Xin-Sheng Lu, Xing Tian, Xiao-Nan Zheng, Xing-Quan Zhu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-04-01
Edice:	Parasites & Vectors
Témata:	Toxoplasma gondii Rhoptry proteins Clustered regularly interspaced short palindromic repeats Clustered regularly interspaced short palindromic repeats-associated protein 9 Virulence Transcriptomics
On-line přístup:	https://doi.org/10.1186/s13071-026-07387-0
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