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A Detailed Analysis of Parameters Supporting the Engraftment and Growth of Chronic Lymphocytic Leukemia Cells in Immune-Deficient Mice

Patient-derived xenograft models of chronic lymphocytic leukemia (CLL) can be created using highly immunodeficient animals, allowing analysis of primary tumor cells in an in vivo setting. However, unlike many other tumors, CLL B lymphocytes do not reproducibly grow in xenografts without manipulation...

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Principais autores: Piers E. M. Patten, Gerardo Ferrer, Shih-Shih Chen, Jonathan E. Kolitz, Kanti R. Rai, Steven L. Allen, Jacqueline C. Barrientos, Nikolaos Ioannou, Alan G. Ramsay, Nicholas Chiorazzi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-03-01
coleção:Frontiers in Immunology
Assuntos:
chronic lymphocytic leukemia
patient-derived xenograft
engraftment
growth
T cells
B cells
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2021.627020/full
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