L-DOPA-induced dyskinesia and abnormal signaling in striatal medium spiny neurons: focus on dopamine D1 receptor-mediated transmission

Dyskinesia is a serious motor complication caused by prolonged administration of L-DOPA to patients affected by Parkinson’s disease. Accumulating evidence indicates that L-DOPA-induced dyskinesia (LID) is primarily caused by the development of sensitized dopamine D1 receptor (D1R) transmission in th...

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Principais autores:	Michael eFeyder, Alessandra eBonito Oliva, Gilberto eFisone
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2011-10-01
Series:	Frontiers in Behavioral Neuroscience
Assuntos:	Basal Ganglia Parkinson’s disease cAMP dopamine- and cAMP-regulated phosphoprotein 32 kDa extracellular signal-regulated protein kinases Immediate early genes
Acceso en liña:	http://journal.frontiersin.org/Journal/10.3389/fnbeh.2011.00071/full
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