Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB

A significant subpopulation of neurons in rat nucleus accumbens (NAc) coexpress dopamine D1 and D2 receptors, which can form a D1-D2 receptor complex, but their relevance in addiction is not known. The existence of the D1-D2 heteromer in the striatum of rat and monkey was established using in situ P...

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Autors principals:	Ahmed Hasbi, Melissa L. Perreault, Maurice Y. F. Shen, Theresa Fan, Tuan Nguyen, Mohammed Alijaniaram, Tomek J. Banasikowski, Anthony A. Grace, Brian F. O'Dowd, Paul J. Fletcher, Susan R. George
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2018-01-01
Col·lecció:	Frontiers in Pharmacology
Matèries:	addiction and addiction behaviors dopamine D1-D2 heteromer DARPP-32 deltaFosB dopamine signaling proximity ligation assay
Accés en línia:	http://journal.frontiersin.org/article/10.3389/fphar.2017.00924/full
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