Formation of Condition‐Dependent Alpha‐Synuclein Fibril Strain in Artificial Cerebrospinal Fluid

Abstract α‐Synuclein (aSyn) is an intrinsically disordered protein involved in neurotransmission and synaptic plasticity. The pathological aggregation of this protein is a hallmark of synucleinopathies such as Parkinson's disease (PD) or Multiple System Atrophy (MSA). Misfolded aSyn, which primarily...

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Auteurs principaux:	Rūta Sniečkutė, Darius Šulskis, Arūnė Jocytė, Urtė Venclovaitė, Rimgailė Tamulytė, Mantas Žiaunys, Vytautas Smirnovas, Andrius Sakalauskas
Format:	Artigo
Langue:	Inglês
Publié:	Wiley 2026-02-01
Collection:	Advanced Science
Sujets:	aggregate structure analysis alpha‐synuclein aggregation Cryo‐EM Parkinson's disease physiological conditions
Accès en ligne:	https://doi.org/10.1002/advs.202505228
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