Formation of Condition‐Dependent Alpha‐Synuclein Fibril Strain in Artificial Cerebrospinal Fluid

Abstract α‐Synuclein (aSyn) is an intrinsically disordered protein involved in neurotransmission and synaptic plasticity. The pathological aggregation of this protein is a hallmark of synucleinopathies such as Parkinson's disease (PD) or Multiple System Atrophy (MSA). Misfolded aSyn, which primarily...

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Bibliografiske detaljer

Principais autores:	Rūta Sniečkutė, Darius Šulskis, Arūnė Jocytė, Urtė Venclovaitė, Rimgailė Tamulytė, Mantas Žiaunys, Vytautas Smirnovas, Andrius Sakalauskas
Format:	Artigo
Sprog:	Inglês
Udgivet:	Wiley 2026-02-01
Serier:	Advanced Science
Fag:	aggregate structure analysis alpha‐synuclein aggregation Cryo‐EM Parkinson's disease physiological conditions
Online adgang:	https://doi.org/10.1002/advs.202505228
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