Identifying, handling and impact of immortal time bias on addressing treatment effects in observational studies using routinely collected data

Abstract Background Immortal time bias (ITB) represents a methodological challenge in evaluating treatment effects in observational studies using routinely collected data (RCD). However, the prevalence of ITB, the strategies used to address ITB and its impact remain inadequate. This study aimed to i...

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Bibliographic Details

Main Authors:	Shuangyi Xie, Jiayue Xu, Qiao He, Yuning Wang, Qianrui Li, Xia Zhang, Yunxiang Huang, Yuanjin Zhang, Wen Wang, Xin Sun
Format:	Artigo
Language:	Inglês
Published:	BMC 2025-12-01
Series:	BMC Medical Research Methodology
Subjects:	Routinely collected data Drug treatment effect Immortal time bias Time-varying treatment
Online Access:	https://doi.org/10.1186/s12874-025-02739-3
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