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Upregulation of Chemoresistance by Mg<sup>2+</sup> Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells

Several anticancer drugs including cisplatin (CDDP) induce hypomagnesemia. However, it remains fully uncertain whether Mg<sup>2+</sup> deficiency affects chemosensitivity of cancer cells. Here, we investigated the effect of low Mg<sup>2+</sup> concentration (LM) on proliferation and chemosensitivity...

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Principais autores: Saki Onuma, Aya Manabe, Yuta Yoshino, Toshiyuki Matsunaga, Tomohiro Asai, Akira Ikari
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-05-01
Serier:Cells
Fag:
lung adenocarcinoma
chemoresistance
ABCB1
hypomagnesemia
Online adgang:https://www.mdpi.com/2073-4409/10/5/1179
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