Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer
Abstract Intratumoral heterogeneity is caused by genomic instability and phenotypic plasticity, but how these features co-evolve remains unclear. SOX10 is a neural crest stem cell (NCSC) specifier and candidate mediator of phenotypic plasticity in cancer. We investigated its relevance in breast canc...
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| Principais autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2022-05-01
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| coleção: | npj Breast Cancer |
| Acesso em linha: | https://doi.org/10.1038/s41523-022-00425-x |
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