क्यूआर कोड

Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer

Abstract Intratumoral heterogeneity is caused by genomic instability and phenotypic plasticity, but how these features co-evolve remains unclear. SOX10 is a neural crest stem cell (NCSC) specifier and candidate mediator of phenotypic plasticity in cancer. We investigated its relevance in breast canc...

पूर्ण विवरण

में बचाया:
मुख्य लेखकों: Jodi M. Saunus, Xavier M. De Luca, Korinne Northwood, Ashwini Raghavendra, Alexander Hasson, Amy E. McCart Reed, Malcolm Lim, Samir Lal, A. Cristina Vargas, Jamie R. Kutasovic, Andrew J. Dalley, Mariska Miranda, Emarene Kalaw, Priyakshi Kalita-de Croft, Irma Gresshoff, Fares Al-Ejeh, Julia M. W. Gee, Chris Ormandy, Kum Kum Khanna, Jonathan Beesley, Georgia Chenevix-Trench, Andrew R. Green, Emad A. Rakha, Ian O. Ellis, Dan V. Nicolau, Peter T. Simpson, Sunil R. Lakhani
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Portfolio 2022-05-01
श्रृंखला:npj Breast Cancer
ऑनलाइन पहुंच:https://doi.org/10.1038/s41523-022-00425-x
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