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Impact of Oxygen Availability on the Organelle‐Specific Redox Potentials and Stress in Recombinant Protein Producing Komagataella phaffii

ABSTRACT The yeast Komagataella phaffii (syn. Pichia pastoris) is a highly effective and well‐established host for the production of recombinant proteins. The redox balance of its secretory pathway, which is multi‐organelle dependent, is of high importance for producing secretory proteins. Redox imb...

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Principais autores: Aliki Kostopoulou, Corinna Rebnegger, Borja Ferrero‐Bordera, Matthias Mattanovich, Sandra Maaß, Dörte Becher, Brigitte Gasser, Diethard Mattanovich
פורמט: Artigo
שפה:Inglês
יצא לאור: Wiley 2025-02-01
סדרה:Microbial Biotechnology
נושאים:
chemostat cultivation
glutathione redox potential
hypoxia
Komagataella phaffii
yeast
גישה מקוונת:https://doi.org/10.1111/1751-7915.70106
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