UsnRNP trafficking is regulated by stress granules and compromised by mutant ALS proteins

Activation of the integrated stress response (ISR), alterations in nucleo-cytoplasmic (N/C) transport and changes in alternative splicing regulation are all common traits of the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). However, whether these processes act independently from each other, o...

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Autors principals:	Simona Rossi, Valentina Rompietti, Ylenia Antonucci, Daniela Giovannini, Chiara Scopa, Silvia Scaricamazza, Raffaella Scardigli, Gianluca Cestra, Annalucia Serafino, Maria Teresa Carrì, Nadia D'Ambrosi, Mauro Cozzolino
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2020-05-01
Col·lecció:	Neurobiology of Disease
Matèries:	ALS Nucleo-cytoplasmic transport Integrated stress response Stress granules Cajal bodies Gems
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S096999612030067X
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