Ciliary p75 neurotrophin receptor (p75NTR) facilitates the enrichment of exogenous amyloid beta (Aβ 1–42) peptide and promotes oxidative stress in human hippocampal astrocytes

Abstract Accumulation of amyloid beta 1–42 (Aβ42) peptide in the extracellular space in the brain is a major observation in Alzheimer’s Disease (AD)-related pathology. Astrocytes are known to play pivotal role in clearing the extracellular aβ peptide from the brain, and the underlying mechanism of A...

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Autors principals:	Ankan Gupta, Karthikeyan Thirugnanam, Zachary Bice, Allison K. Lowman, Kevin R. Rarick, Peter S. LaViolette, Amy Pan, Malgorzata Franczak, Ramani Ramchandran
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2026-03-01
Col·lecció:	BMC Molecular and Cell Biology
Matèries:	Hippocampus Dementia Alzheimer disease Reactive oxygen species Oxidative stress Cell cycle
Accés en línia:	https://doi.org/10.1186/s12860-026-00581-z
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