Application of the estimand framework for an emulated trial using reference based multiple imputation to investigate informative censoring

Abstract Background The ICH E9 (R1) addendum on Estimands and Sensitivity analysis in Clinical trials proposes a framework for the design and analysis of clinical trials aimed at improving clarity around the definition of the targeted treatment effect (the estimand) of a study. Methods We adopt the...

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Auteurs principaux:	A. Atkinson, M. Zwahlen, S. De Wit, H. Furrer, J. R. Carpenter
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2024-10-01
Collection:	BMC Medical Research Methodology
Sujets:	Estimand framework Informative censoring Multiple imputation Sensitivity analysis Trial emulation
Accès en ligne:	https://doi.org/10.1186/s12874-024-02364-6
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